Expression of Lead Proteins

The Lead Protein Challenge

Every drug developer seeks to rapidly identify a robust host strain early in the clinical development lifecycle that can be scaled throughout clinical development and commercialization to meet product demand. Identifying a host strain producing high titers of soluble active protein is critical to minimizing long term cost of goods as well as avoiding potential regulatory delays due to poor protein quality or insufficient productivity of the selected host.

The Pfēnex Lead Protein Solution:

Pfēnex Expression Technology leverages its broad toolbox and high throughput robotically enabled strain screening platform to screen hundreds of strains to rapidly identify the ideal production strain that is expressing the highest titers of soluble, active high quality protein. Pfēnex scientists routinely go from DNA to an identified production strain within 8 weeks, enabling our partners’ clinical development programs to proceed and keeping CMC off of the critical path.