Product Pipeline

Pfenex is a leading-edge biologics company driven by the desire to provide access to safe, effective, affordable products to market.

We have the highest-quality protein production and bioanalytic technology platform approach that allows us to create biosimilars in a highly efficient manner from concept to commercialization.

We are one of the only companies focused on non-glycosylated biosimilars, creating a differentiated platform approach and competitive advantage. This focus allows us to ensure a robust pipeline of high-quality therapeutics.

In addition, our unique protein production platform is well suited to vaccine development. By capitalizing on our ability to rapidly identify production strains for proteins that cannot be readily produced in other systems we are able to conduct infectious disease research and vaccine development previously not possible.

See our complete product pipeline below.

Therapeutics

PRECLINICAL/
BIOANALYTICAL
CHARACTERIZATION
CLINICAL
COMPARATIVE
STUDY
APPROXIMATE
ANNUAL
BRANDED
SALES
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PF530

Interferon beta-1b biosimilar

(Betaseron)

$1.2B*

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PF530 Biologic Betaseron marketed by Bayer
Global 2014 sales: $1.2 billion*
Used to treat relapsing multiple sclerosis
Most advanced Betaseron biosimilar in development
Phase 1 trial initiated in March 2015

PF529

Peg-filgrastim biosimilar

(Neulasta)

$4.6B*

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PF529 Biologic Neulasta marketed by Amgen
Global 2014 sales: $4.6 billion*
Used to reduce infections during chemotherapy

PF688

Certolizumab- pegol biosimilar

(Cimzia)

$1.2B*

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PF688 Biologic Cimzia marketed by UCB
Global 2014 sales: $1.2 billion*
Used for the treatment of Crohn's disease and rheumatoid arthritis

PF708

Teriparatide generic

(Forteo)

$1.3B*

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PF708 Innovator drug Forteo marketed by Eli Lilly
Global 2014 sales: $1.3 billion*
Used for the treatment of high fracture risk osteoporosis
Bioequivalence study initiated in 2015
$8.3
Billion
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PF582

Ranibizumab biosimilar

(Lucentis)

$4.5B*

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PF582 Biologic Lucentis marketed by Hoffmann-La Roche and Novartis AG
Global 2014 sales:$4.5 billion*
Used for the treatment of retinal diseases
Expected to initiate Phase 3 equivalence study in 2016
$4.5
Billion
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PF444

Human Growth Hormone biosimilar

(Genotropin)

$3.4B*

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PF444 Biologic Genotropin marketed by Pfizer
Global 2014 sales: $3.4 billion*
Used to treat certain growth disorders

PF694

Peg-interferon alpha- 2a biosimilar

(Pegasys)

$905MM*

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PF694 Biologic Pegasys marketed by Hoffmann-La Roche
Global 2014 sales: $905 million*
Used for the treatment of chronic hepatitis C

PF690

Peg-aspargase biosimilar

(Oncaspar)

$100MM**

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PF690 Biologic Oncaspar marketed by Sigma-Tau
Global 2014 sales: $100 million**
Used for the treatment of Acute Lymphoblastic Leukemia
$4.4
Billion

*Approximate 2014 global branded sales of third party reference drug per IMS data accessed on 11/25/15

** Baxter Press Release – May 12, 2015
Last Updated: 1/22/16

Novel Vaccines

  PRE-CLINICAL PHASE 1 PHASE 2
arrowRight FULLY FUNDED BY THE
US GOVERNMENT
     

Px563L

SDI rPA based Anthrax Vaccine 2nd Generation

Px533

Malaria Vaccine

Px563L

rPA based Anthrax Vaccine

Last Updated: 1/22/16

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